Organic Synthesis And Named Reactions Mock Tests

The Mitsunobu reaction of (R)-1-phenylethanol with benzoic acid using triphenylphosphine and diethyl azodicarboxylate (DEAD) proceeds with:

The electrocyclic ring opening of cis-3,4-dimethylcyclobutene under thermal conditions gives which stereoisomer of 1,3-butadiene?

Which of the following compounds undergoes nucleophilic aromatic substitution (NAS, S_NAr) with sodium methoxide (NaOCH₃) in methanol at the fastest rate? (Consider the mechanism of S_NAr, which proceeds via a Meisenheimer complex intermediate. Electron-withdrawing groups, especially at ortho and para positions, stabilize the anionic intermediate and accelerate the reaction.)

The Heck coupling of styrene with an aryl halide Ar-X gives predominantly which product?

The Wittig reaction of benzaldehyde (C₆H₅CHO) with methyltriphenylphosphonium bromide in the presence of a strong base (n-butyllithium, n-BuLi) yields which product? (The reaction involves deprotonation of the phosphonium salt to form a phosphonium ylide, followed by nucleophilic addition to the carbonyl and formation of an oxaphosphetane intermediate.)

The Wolff-Kishner reduction converts aldehydes and ketones to alkanes using which reagent system?

The Heck coupling reaction between bromobenzene and methyl acrylate (methyl propenoate, CH₃OOC−CH=CH₂) catalysed by Pd(OAc)₂ with triphenylphosphine and a base (Et₃N) yields which major product? (Consider the regioselectivity of the migratory insertion step and the preference for forming the more stable trans (E) alkene.)

The crossed aldol condensation between benzaldehyde (C₆H₅CHO) and acetone (CH₃COCH₃) in the presence of aqueous NaOH, followed by heating, primarily yields: