Organic Synthesis And Named Reactions Mock Tests

The Heck coupling reaction between bromobenzene and methyl acrylate (methyl propenoate, CH₃OOC−CH=CH₂) catalysed by Pd(OAc)₂ with triphenylphosphine and a base (Et₃N) yields which major product? (Consider the regioselectivity of the migratory insertion step and the preference for forming the more stable trans (E) alkene.)

The Suzuki-Miyaura cross-coupling reaction between bromobenzene and phenylboronic acid in the presence of a Pd(0) catalyst and base yields which product as the major organic compound? (The reaction is typically carried out in a mixture of water and an organic solvent such as THF or dioxane with Na₂CO₃ as the base.)

In the retrosynthetic analysis of 1-phenylbutan-1-one (C₆H₅COCH₂CH₂CH₃, also known as butyrophenone), which of the following represents the most logical synthetic disconnection using the Friedel-Crafts acylation strategy? (Consider the directness of the approach, the regioselectivity of electrophilic aromatic substitution, and the compatibility of the reagents.)

The Heck coupling of styrene with an aryl halide Ar-X gives predominantly which product?

The Wolff-Kishner reduction converts aldehydes and ketones to alkanes using which reagent system?

Which of the following compounds undergoes nucleophilic aromatic substitution (NAS, S_NAr) with sodium methoxide (NaOCH₃) in methanol at the fastest rate? (Consider the mechanism of S_NAr, which proceeds via a Meisenheimer complex intermediate. Electron-withdrawing groups, especially at ortho and para positions, stabilize the anionic intermediate and accelerate the reaction.)

The Norrish Type II reaction of pentan-3-one upon irradiation with UV light gives primarily:

The electrocyclic ring closure of (2E,4Z,6E)-octa-2,4,6-triene under thermal conditions proceeds via which stereochemical pathway, and what is the stereochemistry of the resulting cyclohexene product? (Consider the frontier molecular orbital analysis and the Woodward-Hoffmann rules for a conjugated system with 6 π electrons.)